J Neurol Sci. Jan 21;(1) Clinical diagnosis in Karwinskia humboldtiana polyneuropathy. Martínez HR(1), Bermudez MV, Rangel-Guerra RA. Toxicon. May;53(6) doi: /n Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during. Karwinskia humboldtiana. Karwinskia humboldtiana (Schult.) Zucc. Coyotillo, Humboldt Coyotillo. Rhamnaceae (Buckthorn Family). Synonym(s).

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As an external headache remedy, the leaves were wrapped in a cloth which was in turn tied around the head.

Karwinskia humboldtiana Scientific classification Humboldtiaan Ingestion of the fruit causes damage to nerves as well as the pulmonary system and the liver. Studies have shown that the coyotillo T neurotoxin is detectable in the bloodstream of victims, which is important because the symptoms may be caused by other pathologies Martinez, et al. The Tarahumara crushed coyotillo bark to prepare a tea that was ingested for fevers.

Although many victims recover completely, in serious cases they are left quadriplegic. My concern is that the relaxation might well be permanent. Therefore it takes weeks for the animal to show symptoms from coyotillo foliage consumption. Coyotillo is a very poisonous plant, and stockmen know to introduce only livestock that are familiar with the vegetation of the region, or to feed plenty of supplements to those animals that aren’t.

Despite its deservedly poisonous reputation, coyotillo seeds, branches, and leaves were recovered from Early Archaic, Middle Archaic, and Late Archaic contexts at Hinds Cave Dering However, consumption of fruit is much more deadly.

Clinical diagnosis in Karwinskia humboldtiana polyneuropathy.

Views Read Edit View history. Karwinskia humboldtiana fruit Kh causes a neurological disorder weeks after ingestion, characterized by flaccid, humboldtiqna, ascending paralysis, similar to the Guillain-Barre syndrome.


Its common name in Mexico, tullidora, is rendered from the verb “tullir,” to cripple. It was actually eaten as starvation food in June, but over-consumption caused a serious stomach ache.

Karwinskia humboldtiana – Wikipedia

Journal of Neurological Science 1: We designed an open trial at the Pediatric Neurology service and included all cases with acute ascending paralysis that were admitted to our hospital in the last two years.

The fruit is the most poisonous part of the Coyotillo plant, or, at least the seed inside the fruit. This Rhamnaceae article is a stub. This is the first report about the presence of neuronal damage caused by Kh in the Central Nervous System in chronic intoxication. Coyotillo contains potent neurotoxins, the most prominent of which are tullidinol toxin T and peroxisomicine toxin T In two of these cases, a sural nerve biopsy revealed a segmental demyelination with swelling and phagocytic chambers in Schwann cells and without lymphocytic infiltration.

Their Environment and Material Culture. New York, New York: Karwinskia humboldtianacommonly known as coyotillocacachila or Humboldt coyotillois a species of flowering shrub or small tree in the buckthorn family, Rhamnaceae.

Electrodiagnostic studies were performed, including motor conduction velocities, distal latencies, F-wave latency and compound muscle action potential CAMP amplitude. However, raccoon, coyote, and fox appear to eat the berries and survive, because the scat of these animals is loaded with coyotillo seeds when the fruit is ripe.

We considered it important to evaluate, with histological techniques, the possible presence of lesions in the brain, by using a model of chronic intoxication that reproduces the same stages present in the human intoxication, to better understanding of this pathological process. Algonquin Books of Chapel Hill. Spasms and paralysis in the extremities are the first observable symptoms of coyotillo poisoning, which often spreads to affect breathing or liver function, ending in death.


From Wikipedia, the free encyclopedia. Rhamnaceae Buckthorn Family Coyotillo is a small, evergreen shrub with deep green, almost glossy and distinctively veined leaves that grow opposite each other along the stem.

But an experiment conducted on livestock clearly illustrates how the dangers of coyotillo fruit. However, the leaves and the fruit, especially the seed inside the exocarp contain deadly neurotoxins. You can help Wikipedia by expanding it. Goats, sheep, and cattle are all susceptible Lyons and Machen However, it often takes days or even weeks after consumption for the symptoms to manifest.

Children exhibiting symptoms of coyotillo poisoning, including shakes or “palsies” were seen by outside observers. In other projects Wikimedia Commons Wikispecies. However, he does note that a tincture of the leaves was used as an anticonvulsive for treating paralysis from tetanus, until the muscles relax.

Intoxication with buckthorn (Karwinskia humboldtiana): report of three siblings.

This page was last edited on 25 Augustat The presence of Karwinskia humboldtiana toxins in blood were determined by thin layer chromatography. It only takes 0. Only one patient required assisted ventilation due to bulbar paralysis.

Indeed, the Tepehuan boil the bark for several hours and ingest the resultant tea for fevers, identical uses to the Tarahumara that the ethnographer duly noted Pennington ;